Shares pulled back further on Wednesday following a blow for miners and lacklustre performances on Wall Street and in Asia.
Shortly after opening, London's leading index was almost 50 points, or 0.88%, lower at 5,658.
A fall in raw materials prices weakened mining shares, with Kazakhmys, Xstrata, Eurasian Natural Resources, Rio Tinto and Anglo American all more than 2% down.
Sentiment was also hit following disappointing results in the US and Asia.
Improved consumer confidence across the Atlantic failed to translate into positive market activity, with the Dow Jones closing just five points higher at 11,169.
Meanwhile, in Asia, stock markets were mostly lower with Tokyo's market giving up early gains.
Japan's Nikkei Stock Average closed marginally higher but Australia's S&P/ASX 200 shed 0.9%, and South Korea's Kospi Composite was down 0.3%.
Hong Kong's Hang Seng Index dropped 1.75%, and China's Shanghai Composite fell 0.3%.
Caring for children and elderly relatives
Similar to June 2007
Square Mile’s series of informal interviews
Fine reduced to £60,000
Two roles created