A sluggish opening on the FTSE has seen the index slide 31 points, or 0.51%, but it remains over 6,000 at 6,045.5.
Rentokil, which has dropped 26.6p, or 25.33%, to 78.4p, Xstrata and Kingfisher are all down.
However, gains for Whitbread, up 73p, or 5.95%, to £12.99, Enterprise Inns, Aviva, British American Tobacco and British Energy Group are all having positive Thursdays so far.
In the US, the Dow Jones made marginal gains, climbing 9.36 points, or 0.07%, to 12,694.28.
International Business Machines had the strongest day, climbing 2.08 points to 116.46, but was swiftly followed by American International Group, JPMorgan Chase, Alcoa and Caterpillar.
However, Merck & Co fell 0.95 points, or 2.05%, to 45.44, and was joined in the red by McDonalds and Verizon Communications.
Japanese stocks fell for a second time this week, led by automakers and electronics companies, after manufacturers forecast factory production will slow and the yen strengthened against the dollar.
The Nikkei 225 Stock Average declined 105.79, or 0.8%, to close at 13,925.51 in Tokyo.
020 7034 2636
Latest news and analysis
PA360 2019 revisited
Sector regulated by FPA
Future World funds
Achievements, charity work and other happy snippets