News of a Fed rate cut in the US has failed to buoy the FTSE in early trading on Wednesday, the index dropping 51.9 points, or 0.93%, to 5553.9.
Experian has made the largest early gains, climbing 10.5p to 370.75, followed by Smiths Group, up 21p to 968p, and Yell Group.
However, these gains are being stemmed by significant losses for HBOS down 41.5p, or 8.64%, to 438.75p, and retail group Next, down 66p to £11.13.
The Royal Bank of Scotland is also suffering in early trading and has dropped 17.25p in share value to 308.75p.
No such trouble in the US, where the Dow Jones is flying after the Federal Reserve intervention.
The index climbed 420.41 points yesterday, or 3.51%, to 12,392.66, and not a single Dow Jones company lost share value.
American International Group was the day’s biggest winner, gaining 3.87 points, or 9.72%, to 43.67.
It was closely followed by GEN Motors, up 1.58 points, or 8.86%, to 19.41, and JPMorgan Chase, up 2.4 points, or 5.95%, to 42.71.
Home Depot and American Express also made it into the day’s top five winners.
Japanese stocks surged after US investment bank earnings eased concern more global brokerages will fail and the Fed interest-rate cut led to the dollar's biggest rally against the yen in nine years.
The Nikkei 225 Stock Average climbed 296.28 points, or 2.5%, to close at 12,260.44.
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