The FTSE 100 is down 27 points, or 0.42%, to 6,442.4, as a poor start for the mining sector is dragging the index lower.
BHP Billiton is the biggest loser with a fall of 1.83% to £11.24, closely followed by Vedanta Resources which is down 1.49% to £13.87, while Anglo American has dropped 1.34% to £26.46.
Xstrata has also fallen 1.32% to £26.13, while British Land has dropped 1.22% to £14.59, although losses are being limited by Marks & Spencer Group which is up 1.28% to 750.5p.
Scottish & Newcastle is posting the biggest gains with a rise of 4.61% to 612.5p, closely followed by ITV which has added 2.07% to 118.3p, while SABMiller has climbed 1.44% to £11.96, and Next has advanced 1.27% to £23.17.
In Japan, the Nikkei 225 Stock Average fell 28.76, or 0.17%, to 17,400.41 at the 3pm close, after government reports showed industrial output unexpectedly fell.
Sharp, Japan's largest maker of liquid-crystal displays, fell 3.3% to 2,210 yen and Canon, the world's No. 1 digital camera maker, lost 0.9% to 6,750 yen, while Mitsubishi UFJ, Japan's largest lender, declined 2.3% to 1.25 million yen, and Resona Holdings, the fourth biggest, slid 2.2% to 272,000 yen.
Among the banks Acom, which is 15% owned by Mitsubishi UFJ, fell 3.4% to 4,330 yen, after it announced a net loss of 437.9 billion yen for the year ending 31 March, while Nintendo, the world's biggest maker of handheld game players, climbed 1.8% to 37,850 yen, as profit had climbed to 174 billion yen for the year.
In the US, the Dow Jones Industrial Average climbed 15.61 points, or 0.12%, to 13,105.5, as another batch of strong earnings reports pushed the index to a new record close.
Altria Group was the biggest loser with a fall of 1.62% to $69.33, closely followed by Home Depot which ended down 1.29% to $38.99, while Procter & Gamble 0.85% to $62.99.
Du Pont dropped 0.78% to $49.58, while Intel slipped 0.75% to $22.09, although losses were offset by Verizon Communications which added 0.85% to $37.97, while McDonald’s climbed 1.23% to $49.23.
However 3M Company posted the biggest gains with a rise of 4.52% to $80.45, closely followed by General Motors which advanced 4.44% to $32.45, while drug company Pfizer gained 1.52% to $26.72.
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