The UK's FTSE 100 index has closed lower for a third consecutive day.
The benchmark ended up losing a further 35.1 points to 4783.60 points, led by UK drugmaker Shire Pharmaceuticals shedding 16p to 599p, while GlaxoSmithKline was down 26p to to 1197p.
Prudential also slipped 10.25p to 452.25p.
Hanson, the world's largest producer of sand and gravel, led the FTSE gains, adding 19.25p, or 4% to 481p.
The bounce in the building market comes as cement firm Holcim, offered £1.78bn for Aggregate Industries to acquire a maker of crushed rock for building and expand in the UK and US.
Johnson Matthey a chemicals company focussing on catalysts, precious metals and speciality chemicals, picked up 31p to 999p.
In the US, the Dow Jones continues its poor run shedding 28.45 to 10,527.77 points in morning trading.
Hewlett-Packard paces the Benchmark, down $0.25 to $19.80, along with Gen Motrors, down $0.35 to $38.10.
The dollar meanwhile, dropped by the most in five weeks against the euro and declined against the yen, after the US trade deficit surprisingly expanded to a record in November.IFAonline
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