Angela Knight is to step down as chief executive of the British Bankers' Association (BBA) this summer.
Knight joined the BBA in April 2007 a few months before the run on Northern Rock and the beginning of the credit crunch.
The BBA is yet to appoint a successor.
Knight described her time at the BBA as "one of extraordinary difficulty".
But she said: "The BBA has played a strong part throughout this challenging period and has helped the industry it represents with the significant changes to regulation and legislation required.
The UK banking industry has already undergone radical restructuring to make it fit for the future and I am pleased to have played a part in this."
Marcus Agius, chairman of the BBA, said: "Angela has been instrumental in overseeing the BBA's development as the key voice in the debate on the future of the banking sector. I wish her all the best for the future."
What made financial headlines over the weekend?
To promote 'long-term investment'
Switching 'hard and expensive'
Smaller funds still packing a punch