House prices fell 3.6% in September according to the Halifax, the biggest month-on-month decline since it began keeping records in 1983.
September's drop followed the 4.6% rise reported in August, with the average UK home now valued at £162,096.
However, the bank said it was too early to conclude this was the start of a sustained fall in prices, adding prices remained 2.6% higher than a year ago.
Low transaction levels contributed to the volatility in the month-on-month measure of house prices, Halifax housing economist Martin Ellis said.
"Prospects for the housing market remain uncertain.
"Earnings growth is expected to be very modest over the next year, tax rises are on the way and more people are putting their homes on the market.
"These will all be constraints, dampening house prices."
However, he added: "On the positive side, we expect interest rates to remain very low for some time, which will underpin the improved affordability position for homeowners."
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