The FTSE 100 regained some of the ground it lost today in late trading, but still closed down 0.8% lower at 5,211 points.
European markets were also lower, with France's Cac 40 off 1.4% at 3,582, while the Dax in Frankfurt was 0.97% down at 6,149.
The Dow Jones followed Europe in early trading, 1% lower at 10,261.75 points.
In London, mid-cap Gartmore was down 5.7% at 103.8p. It fell 8% to 101p in early trading on news former star manager Guillaume Rambourg had resigned.
Elsewhere among financial stocks, Fidelity China Special Situations is up 1% to 100.2p after manager Anthony Bolton spoke to journalists this morning.
Miners failed to recover much ground after their outlook was clouded overnight by a report showing slowing GDP growth in China, the world's largest consumer of raw commodities.
UK major miners started the day down between 2% and 3%. By mid-afternoon, BHP Billiton was off 1.5%; Vedanta Resources was 2.5% lower; Xstrata was 2.8% down; and Kazakhmys was 2.7% down. Rio Tinto is still 3.7% lower.
Essar Energy is up 2.9% at 441.5p on news its Indian subsidiary will buy a local coal-fired power plant project.
Similarly, Experian continues this morning's climb, up 1.9% at 645.5p, after announcing second quarter revenues grew 7%. Charles Stanley reiterated its buy recommendation.
GlaxoSmithKline rose 1.5% to £11.99 after the US Food and Drug Administration agreed to allow its diabetes drug Avandia to stay on the market.
Glaxo is paying out £1.57bn to settle legal claims, one of which involves Avandia.
BP is down 0.4% on news US politicians are trying to ban it winning further offshore US drilling leases for seven years.
Alzheimer’s is the most common cause of dementia
Total of 72 accredited firms
23% fall since Q1
Achievements, charity work and other happy snippets
Including advice firm Chadkirk WM