Henderson's head of UK wholesale Laurie Jaques has left the firm to pursue opportunities elsewhere.
Jaques' departure follows Henderson's hire of Simon Hillenbrand, Greg Jones and James Bowers last week.
Jaques joined Henderson in April 2007 from Skandia where he was head of product sales.
Both Hillenbrand and Jones will report to head of pan-European retail business Mark Skinner, while Bowers will report to Stewart Cazier.
Clarke replacing Balkham
'Deep-dive analysis of client behaviour'
Ways to mitigate April’s increases
The best equity income funds examined