The FTSE 100 has ended the day down 23.9 points, or 0.39%, to 6,160.9 as a late rally by energy stocks limited losses.
Building materials group Hanson was the biggest drag on the index with a drop of 4.44% to 711p, closely followed by WPP which dropped 2.03% to 675p, while Reuters Group slipped 2.01% to 451.25p.
Drug stocks also suffered with AstraZeneca falling 3.77% to £31.39, while GlaxoSmithKline slipped 2.83% to £14.10, as brokers cut their forecasts following disappointing news on their drug pipelines.
However British Energy posted the biggest gains with a rise of 3.71% to 419.5p, closely followed by Drax Group which gained 2.29% to 804p, while Scottish & Southern Energy climbed 1.69% to £13.21.
In the US the Dow Jones Industrial Average is down 17.13 points, or 0.14%, to 12,146.53, on news the economy is growing at its weakest pace for three years.
Wal-Mart Stores is the biggest drag on the index with a drop of 1.1% to $51.18, closely followed by heavy equipment maker Caterpillar which is down 0.96% to $61.75, while Intel has slipped 0.87% to $21.59.
Johnson & Johnson has fallen 0.87% to $68.22, closely followed by Merck which has dropped 0.8% to $45.84, although losses are being limited by Pfizer which is up 0.55% to $27.43.
Alcoa is posting the biggest gains so far with a rise of 2.54% to $28.31, while Boeing has climbed 1.05% to $79.97, Microsoft has added 0.78% to $28.57, and Exxon Mobil has gained 0.59% to $72.04.IFAonline
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