The FTSE 100 index has ended the day down 47.5 points or 0.75% to 6,291.9, over fears about the strength of the US economy.
Persimmon posted the biggest gains with a rise of 2.64% to £14.37, closely followed by Smith & Nephew which advanced 1.25% to 648p, while Home Retail added 0.96% to 448p.
Rolls-Royce Group climbed 0.93% to 488.5p, while Imperial Tobacco Group added 0.72% to £22.31, although gains were offset by miner Antofagasta which declined 2.35% to 508.5p.
Insurer Prudential was the biggest loser with a fall of 2.63% to 723p, closely followed by British Airways which slipped 2.61% to 504.5p, while Whitbread dropped 2.53% to £18.88, and Unilever declined 2.44% to £14.80.
In the US, the Dow Jones Industrial Average is down 78.67 points, or 0.63%, to 12,402.34, following an unexpected drop in home sales for February.
Verizon Communications is the biggest faller with a drop of 1.65% to $37.49, closely followed by Honeywell International which is down 1.47% to $47.01, while Alcoa has slipped 1.35% to $33.73.
Wal-Mart has declined 1.09% to $47.39, while United Technologies has slipped 1.08% to $66.01, and so far just three stocks are making gains, with AT&T leading the advance with a rise of 0.03% to $38.89, while Disney has added 0.03% to $35, and Exxon Mobil has climbed 0.02% to $75.04.
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An ambitious objective
'Something completely new'
'Illusion of control'
Reasons to be cheerful
Total investment reaches £9m