The FTSE 100 index has lost 20 points or 0.3% to hold just above the psychological barrier at 6004.3 points this morning, led by mining companies including BHP Billiton and Rio Tinto.
BHP Billiton has fallen 0.8% to £11.10 and Rio Tinto has dropped 1.3% to £30.13, having advanced to records yesterday, as metals traded near their highest prices.
Tate & Lyle has also fallen 2.2% to 563p.
In Japan, the Nikkei 225 Stock Average index fell 40.4 points or 0.2% to 17,292.91 points by the 3pm cloe of business in Tokyo after a US report showed slower manufacturing growth and higher prices, heightening concern local shares have risen too far too fast.
Toyota lost 40 yen, or 0.6%, to 6,470 and Honda Motor fell 50 yen, or 0.7%, to 7,340.
Mitsubishi UFJ Financial Group fell 30,000 yen, or 1.6%, to 1.81m, while Mizuho Financial Group lost 3,000 yen, or 0.3%, to 981,000.
Kyocera slid 180 yen, or 1.7%, to 10,540 and Advantest fell 80 yen, or 0.6%, to 14,230.
Among shares which rose, Sumitomo Metal Mining added 20 yen, or 1.2%, to 1,659 and Mitsubishi Materials advanced 14 yen, or 2.2%, to 643 after copper climbed 4.2% in London, earlier reaching a record $5,616 a metric ton. The metal rose 3.4% in New York.
And in the US yesterday, the Dow Jones Industrial Average index finished up 35.62 points or 0.32% at 11,144.94 points.
Earlier in the day, investors had been eager to put new money to work in the market, analysts said, pushing the Dow industrials up more than 100 points to a session high of 11,247.87 and driving other indices up near five-year highs.
But GM said US sales fell 14.6% in March. Its stock fell 5.3%, or $1.13, to $20.14 and helped trim the Dow's advance.
Traders were more optimistic about corporate profits after diversified manufacturer Terex raised its quarterly and full-year profit forecast, prompting a jump of 9.1%, or $7.23, in its stock to $86.47.IFAonline
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