With the market waiting for a decision on interest rates from the Bank of England, shares have drifted lower, cutting the FTSE by about 7 points to 4,481.
Imperial Tobacco is down 29p to 1,201p after a report suggested sales may be slowing in Germany, one of its most important markets.
Astrazenica is down 18p to 2,576 after warnings over safe dosage levels of one of its blockbuster drugs, the anti-cholesterol drug Crestor.
Kingfisher, owner of B&Q, is down 0.5p to 293p after announcing it poached an Ikea executive to lead its Russian operations.
Hanson, the brick maker, is up 2.25p to 427.5p on an analyst upgrade.
Overseas, US markets close down yesterday as leaders of the G8 meeting in Georgia failed to agree on a debt reduction plan for Iraq.
The Dow Jones Industrial Average index shed 64.08 points to 10,368.44, while the broader S&P 500 index fell 10.85 points to 1,131.33.
Stocks gained in Asia, where Tokyo’s Nikkei 225 index added 126.23 points to 11,575.97 earlier this morning. Hong Kong’s Hang Seng index is up about 106 points to 12,446.IFAonline
To promote 'long-term investment'
Switching 'hard and expensive'
Smaller funds still packing a punch
To drive progress