In London, stocks suffered as house builder shares plummeted and major retailers made gloomy sales predictions, with the FTSE 100 losing 53.6 points (0.98%) to 5,426.3.
AstraZeneca added 103p (4.84%) to £22.33 as it won a court case in the US, while fellow drugs firms GlaxoSmithKline gained 43 points (3.9%) to £11.46.
Mark & Spencer shares crashed as it revealed poor sales figures and forecast a gloomy period for at least two years, losing 78p (24.53%) to 240p. Eurasian lost 110 points (9.38%) to £10.65.
On Wall Street, shares fell in the late-morning as concerns about the US economy persisted, and the Dow Jones dropped 33.96 (0.3%) to 11,348.3.
JP Morgan shares added 0.61 (2.38%) to $34.83, while McDonalds climbed 0.56 (0.97%) to $57.85.
General Motors shares slid as Merrill Lynch said it was not impossible the firm could go bankrupt if the US car market fails to pick up, down 1.13 (9.62%) to $10.62. Caterpillar shares lost 2.16 (2.92%) to $71.93.
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