Shares in the UK were unable to respond to more positive economic indicators in the US today, and the FTSE 100 index closed down 29.80 points at 4,489.70.
Mining stocks continue to shed value as fears grew of a pending interest rate hike in China, which would slow growth of commodities exports into that country.
AngloAmerican dropped 28p to 1,135p.
Amvescap dropped 8.5p to 371.75p after its Invesco US fund unit said it was being asked for information about the company by the US Labor Department investigating illegal trading in mutual funds.
Sainsbury dropped 5.25p to 278.5p after announcing the completion of its sale of US assets, first announced earlier this year.
AstraZenica climbed 34p to 2,637p after research on a new lung cancer drug suggested it should be given to more patients sooner than currently recommended.
Abbey jumped 20.5p to 542.5p on speculation it may be acquired by a Hispanic competitor.
Shares in the US are mixed, but the Dow Jones Industrial Average index has managed a 22 points gain to 10,293 so far today on news consumer spending and manufacturing output continue to improve in the US.IFAonline
Paul Bruns and Elaine Parkes
3,000 left to transfer
Record numbers of people aged 90 plus
From 3 to 10 October