In the UK the FTSE 100 Index has lost a further 6.3 points to 4,894.4 points at its close.
Contract catering group Compass leads the drop to the tune of 5% or 12.75p, closing at 241.5p, after the firm issued out its second profit warning in six months.
Smith & Nephew has shed 24.5p or 4.6% to 497.5p, after it received a subpoena from a US attorney's office in a probe into agreements between replacement knee and hip makers and surgeons.
Shire Pharmaceuticals picked up as much as 42.5p or 7.5% to 604.5p, after reporting sales of a hyperactivity drug have steadied following a surprise suspension in Canada earlier this year.
Mining firms Xstrata and Antofagasta also added 28p to £10.10 and 23p to £12,76.
In the US the Dow Jones Industrial Average has given back 32.59 points it gained yesterday to be at 10,508.34 points in its morning session, led by Johnson & Johnson.
The medical device maker, the parent company of Smith & Nephew, has slipped $0.89 to $67.16.
Winners include Exxon Mobil and aluminium firm Alcoa, up $0.77 to $60.01 and $0.33 to$ 30.23 respectively.
Crude oil for May delivery has advanced 2.2% to $55.2 a barrel in New York.IFAonline
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