The FTSE 100 has ended the day down 34.1 points, or 0.55%, to 6,126.8, as the mining sector suffered heavy losses.
Although drug group Shire was the biggest drag on the index with a drop of 2.79% to 940p, after its target price was cut over product delays and competition worries, while Home Retail slipped 2.26% to 399.25p.
Among the miners Kazakhmys fell 2.55% to £11.85, after it announced the level of copper production had increased but other metals had fallen, while Vedanta Resources dropped 2.19% to £14.32, and BHP Billiton fell 2.06% to £10.00.
Hanson posted the biggest gains with a rise of 2.32% to 727.5p, closely followed by Drax which gained 1.62% to 817p, while Kelda Group ended the session up 1.57% to 875.5p.
Insurer Prudential also ended the day up 1.67% to 641p, closely followed by Standard Life which climbed 1.59% to 287.5p, following reports over the weekend that French insurer Axa is considering a £7bn approach for the company.
In the US the Dow Jones Industrial Average is up 11.84 points, or 0.1%, to 12,102.1, as a government report said core consumer prices rose 0.2% in September.
Hewlett-Packard is posting the biggest gains so far with a rise of 1.46% to $39.02, closely followed by Boeing which is up 1.42% to $80.87, while General Motors has climbed 1.15% to $34.32.
Microsoft has added 1.13% to $28.66, closely followed by United Technologies which has gained 1% to $65.59, although gains are being limited by Caterpillar which is down 0.52% to $60.95.
Verizon Communications is the biggest drag on the index with a drop of 3.71% to $37.40 after its results encouraged a bout of profit-taking, while Wal-Mart is down 2.5% to $49.46, and Merck has slipped 0.78% to $45.73.IFAonline
Vitality at Work scheme
Reporting to Steve Hill
Appointed on 19 September
Plans to double size in five years
Unnamed company valuation reduced